Scientist, Molecular Biology - DNA Assembly

At Elegen, we are developing innovative technologies to unlock the SynBio revolution. We are seeking an intensely passionate and creative molecular biologist to become one of the founding members of our growing R&D team, spearheading the development of our revolutionary gene synthesis technology. As a part of our team, they will play a central role in defining and implementing molecular biology strategies for scalable production of long synthetic DNA.

This is a rare and exciting opportunity for a highly motivated and self-driven scientist to get in near the ground floor of a fast moving, very high impact start-up. In addition to working on cutting edge technology, the candidate would help us establish a strong culture of mutual respect, integrity, and collaboration while working alongside some of Silicon Valley’s best scientists and engineers.

 

Primary Responsibilities:

 

● Invent and develop novel molecular biology techniques related to DNA assembly.

 

● Work closely with engineers and external partners to develop protocols for gene synthesis on microfluidic platforms.

 

● Lead the molecular biology efforts through the process scale-up, validation and commercialization stages of the project.

 

● Develop analytical methodologies to aid product development and work closely with bioinformatics to develop sequencing-based QC techniques.

 

● Develop protocols into reproducible standard operating procedures suitable for commercial release and support product documentation.

 

 

Essential Candidate Profile:

 

● Ph.D. in chemistry, molecular biology, synthetic biology or a related field.

 

● Deep expertise in molecular biology techniques. Particularly PCR, gene manipulation, DNA analysis and purification.

 

● Experience in solid phase assay chemistry, preferably related to nucleic acid immobilization and amplification.

 

● Previous experience in devising, troubleshooting and optimizing protocols for molecular biology workflows on automated instrumentation.

 

● Strong track record of working in a highly collaborative environment on multidisciplinary projects.

 

● Self-starter, with a strong passion for developing and implementing new molecular biology techniques.

 

Preferred Candidate Qualifications:

 

● In-depth knowledge of PCR based gene assembly techniques.

 

● In-depth knowledge of PCR troubleshooting of highly multiplexed systems and previous experience with commercialization of PCR based assays.

 

● Experience working with biochemical assays on microfluidic devices, especially reactions on solid supports.

 

● Basic scripting skills in Python.

 

● Working knowledge of synthetic biology techniques, especially de novo gene synthesis, and strong understanding of synthetic biology applications. 

About the company:

 

We are now at the dawn of the synthetic biology revolution, which will spawn new applications, markets, and business models, improving human lives in countless ways. This revolution will be driven by new technologies that enable DNA writing at speed and scale.

 

Founded and led by Dr. Matthew Hill and located in San Carlos, CA, Elegen is well-capitalized by top life science investors, including Andreessen Horowitz, 8VC, and KdT. The company is advised and staffed by leading biotechnology scientists and entrepreneurs, including Dr. Marc Unger, inventor of the Nanoflex™ valve, and former CSO of Fluidigm. Dr. Hill has a PhD from Stanford and a proven track record of advancing innovative technologies from invention to commercial success. Over eight years in his previous role as VP of R&D at a leading molecular diagnostics company, he co-invented and launched five precision molecular diagnostic products, including a best-in-class noninvasive prenatal test used by millions. These products earn more than $350 million per year in revenue and enabled an IPO.